Prof. ±¸  »ó  È£ (sangho Koo)

    Tel :82-31-330-6185, Fax : 82-31-335-7248
    e-mail :
sangkoo@mju.ac.kr

    ¢Â  Education
      
      1981.03 ~ 1985.02 : BS, Seoul National University, Chemistry Major

      1986.01 ~ 1987.05 : MS, The University of Michigan, Organic Chemistry
      1988.09 ~ 1992.08 : Ph. D. The University of Michigan, Organic Chemistry
      1992.09 ~ 1994.02 : Postdoctoral Fellow, Emory University


  
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             1994-1998  ¸íÁö´ëÇб³ È­Çаú Á¶±³¼ö
             1998-1999  ¸íÁö´ëÇб³ È­Çаú ÇаúÀå
             1998-2002  ¸íÁö´ëÇб³ È­Çаú ºÎ±³¼ö
             2006-2013  ¸íÁö´ëÇб³ ³ª³ë°øÇаú ±³¼ö
             2003-ÇöÀç   ¸íÁö´ëÇб³ È­Çаú ±³¼ö

             2006-ÇöÀç   Áß±¹ È­µ¿À̰ø´ëÇб³ Special Visiting Prof.
             2013-ÇöÀç   ¸íÁö´ëÇб³ ¿¡³ÊÁöÀ¶ÇÕ°øÇаú °âÀÓ±³¼ö

             2015-2016  ¸íÁö´ëÇб³ È­Çаú ÇаúÀå
             2017-ÇöÀç   ¸íÁö´ëÇб³ ÀÚ¿¬°úÇдëÇÐ ÇÐÀå
             2019-ÇöÀç   Vice-editor-in-chief (Organic), Journal of Korean Chemical Society

  
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Ä«·ÎƼ³ëÀ̵å°è È­ÇÕ¹° ÇÕ¼º¹ý °³¹ß: ºñŸ¹Î AÀÇ ÀüÀ§Ã¼ÀÌ°í ½Ä¿ë»ö¼Ò·Î »ç¿ëµÇ°í ÀÖÀ¸¸ç ÃÖ±Ù¿¡´Â Ç×¾ÏÈ¿°ú°¡ ÀÖ´Â °ÍÀ¸·Î ¾Ë·ÁÁø Ä«·ÎƼ³ëÀ̵å°è È­ÇÕ¹°ÀÇ ÇÕ¼º¿¡ °üÇÑ ¿¬±¸. Ä«·ÎƼ³ëÀ̵å°è È­ÇÕ¹°ÀÇ ÁÖ¿ä ±¸Á¶¸¦ ÀÌ·ç°í ÀÖ´Â conjugate polyene chainÀÇ È¿À²ÀûÀÎ ÇÕ¼º¹ý °³¹ß. IsopreneÀ» ½ÃÀÛ¹°Áú·Î ¸ÞÆ¿ ġȯüÀÇ À§Ä¡¸¦ ´Þ¸®ÇÏ´Â conjugate polyene unitÀÇ ÇÕ¼º.
 

 

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ÀÔü¼±ÅÃÀûÀÎ polypropionate chain ÇÕ¼º¹ý °³¹ß ¹× À̸¦ ÀÌ¿ëÇÑ Ãµ¿¬¹°ÀÇ ÇÕ¼º ¿©·¯ Ç×»ýÁ¦ÀÇ È¿´ÉÀ» º¸À̰í Àִ õ¿¬¹°µéÀÇ ±¸Á¶¿¡¼­ ÀÚÁÖ ¹ß°ßµÇ´Â polypropionate ±¸Á¶ÀÇ ÀÔü¼±ÅÃÀûÀÎ ÇÕ¼º¹ý °³¹ß. À°°¢Çü °í¸®±¸Á¶¸¦ ±âº»À¸·Î ¿©±â¿¡ ÀÔü¼±ÅÃÀûÀÎ ¹æ¹ýÀ¸·Î ¸ÞÆ¿ ġȯü¸¦ ºÙÀÌ°í °í¸®¸¦ ¿­¾î ¸ÞÆ¿±âÀÇ ´Ù¾çÇÑ ÀÔü±¸Á¶¸¦ °®´Â polypropionate chainÀÇ ÇÕ¼º. ÀÌÀÇ ÀÔü±¸Á¶¸¦ ±âº»À¸·Î °®´Â ¿©·¯ polypropionate °èÅëÀÇ Ãµ¿¬¹° ÇÕ¼º.

 

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´Ù¾çÇÑ °í¸®±¸Á¶ È­ÇÕ¹° ÇÕ¼º¿¡ °üÇÑ ¿¬±¸ º£Å¸-ÄÉÅä¿¡½ºÅ׸£ È­ÇÕ¹°À» ÀÌ¿ëÇÏ¿© ¿À°¢Çü, À°°¢Çü µîÀÇ °í¸®±¸Á¶ È­ÇÕ¹°ÀÇ ÇÕ¼º. ¿©·¯ õ¿¬¹°¿¡¼­ ÀÚÁÖ ¹ß°ßµÇ´Â 2-½ÃŬ·ÎÇÙ¼¾-1-¿Â ¹× 2-½ÃŬ·ÎÆæÅÙ-1-¿ÂÀÇ È¿À²Àû ÇÕ¼º¹ý °³¹ß. À§ÀÇ ¹æ¹ýÀ» ÀÌ¿ëÇÑ ÀÌÁß°í¸®±¸Á¶ È­ÇÕ¹°ÀÇ ÇÕ¼º. Áú¼Ò¿ø¼Ò¸¦ ÇÔÀ¯ÇÏ´Â ÇìÅ×·Î°í¸® È­ÇÕ¹°ÀÇ ÇÕ¼º.


  
   ¢Â  ÁÖ¿ä ³í¹® ½ÇÀû

 

1,2-addition of Dimethyl(phenyl)silyllithium to Cyclic a,b-Unsaturated Ketones and Regiospecific Generation of Cyclic Silyl Enol Ethers through Brook Rearrangement of the1,2-AdditionProducts.
Tetrahedron Letters
, 1990, 31, 831.

 

A General Synthetic Entry to Highly-Oxygenated, Angularly-Fused Polycyclic Aromatic Compound. Liebeskind, L. J. Am. Chem. Soc., 1995, 117, 3389.

 

Allyl Trifluoromethanesulfonate.  Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 19951, 130.

 

Thallium(I) Acetate.  Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, 7, 4832.

 

N-Phenylcampholylhydroxamic Acid.  Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, 6, 3965.

 

Bis(N-propylsalicylideneiminato)cobalt.  Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, 1, 552.

 

3-Nitro-9-nitroso carbazole.  Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, 6, 3747.

 

Highly Efficient Synthesis of Methyl-Substituted Conjugate Cyclohexenone. J. Org. Chem, 1997, 62, 9323.

 

Diallylic Sulfides as Key Structures for Carotenoid Syntheses. J. Org. Chem, 1999, 64, 8051.

   Highly Efficient Synthesis of Bicyclo[3.3.1]nonane Skeleton. Synthesis, 2000, 6, 801-804.
  A Highly Efficient Chain-Extension Process in the Systematic Syntheses of Carotenoid Natural Products. Angew. Chem. Int. Ed 2001, 40, 3627.
  Selective Oxidation of Allylic Sulfindes by Hydrogen Peroxide with the Trirutile-type Solide Oxide Catalyst LiNbMoO6. J. Org. Chem 2001, 66, 8192.
 

Mn(III)-Mediated Radical Cyclization for ¥Ä1-Octalone Synthesis. Bull. Korean Chem, Soc, 2002, 23, 736.

  Allylic sulfones containing triene moieties a key synthons for carotenoid synthesis. Helvetica Chimica Acta 2003, 86, 2620.
  The Friedel-Crafts Alylation of a Preny Group Stabilized by a Sulfone Moiety: Expeditious Syntheses of Ubiquinones and Menaquinones,  J. Org. Chem, 2003, 68, 7925.
  The intramolecular Baylis Hillman reaction: easy preparation of versatile substrates, facile reactions, and synthetic applications. Chem. Commun, 2004, 236.
  Highly Efficient and General Syntehtic Method of Various Retinyl Ethers. Synlett, 2004, 11, 1937.
  Preparetion of the conjugated polyene chains with the 1,4-dimethyl substitution.  Tetrahedron Letters, 2004, 45, 7023.
 

General and systematic synthetic entry to carotenoid natural products. Tetrahedron, 2004, 60, 10181.

 

Stereoselective and Convergent Syntheses of Retinoic Acid and Its Ester Derivatives by the Sulfone Olefination Reaction. Synthesis, 2004, 17, 2813.

 

Efficient Syntheses of the Keto-carotenoids Canthaxanthin, Astaxanthin, and Astacene.  
J. Org. Chem
, 2005, 70, 3328.

 

Preparation  of 1,4-hydrobenzoquinones by the  PCC/SiO2-promoted double  oxidation of 3-cyclohexene-1,2-diols. Org.Biomol.Chem,  2005, 3, 3479.

 

Sulfone  Coupling and Double-Elimination  Strategy for Carotenoid Synthesis. J. Org. Chem, 2005, 70, 9662.

 

TMS·OTf-Catalyzed  ¥á-bromination of carbonyl compounds  by N-bromosuccinimide.
Tetrahedron  Letters
200647, 291.

 

Origin of the Diastereoselection in the Indium-Mediated Addition of Haloallylic Sulfones to Aldehydes.
Organic Letters
, 2006, 8, 1459-1462.

 

Stereoselective  Synthesis of Allylic Sulfones via the Oxonia-Cope Rearrangement of  Homoallylic Alcohols Containing  a Homoallylic Sulfone Moiety. J. Org. Chem, 2006, 71, 4823-4828.

 

General Preparation and Controled Cyclization of Acyclic Terpenoids.
Journal of Organic Chemistry
, 2008, 73, 1991-1994.

 

Expeditious and Practical Synthesis of Lycopene.
Advanced Synthesis & Catalysis
, 2008, 350, 365-369.

 

Ring-Expansion Protocol: Preparation of Synthetically Versatile Dihydrotropones.
J. Org. Chem
, 2009, 74, 917-920.

 

Conductance Control in Stabilized Carotenoid Wires. Chemistry: A European Journal, 2010, 16, 7395 - 7399.

 

Convergent synthesis of new types of stabilized carotenoid compounds.
Pure and Applied Chemistry
, 2011, 83, 3, 613-620.

 

Ultrafast excited state dynamics and spectroscopy of 13,130-diphenyl-b-carotene.
Physical Chemistry Chemical Physics
, 2011,13, 6340-6351.

 

Selective Deoxygenation of Allylic Alcohol: Stereocontrolled Synthesis of Lavandulol.
Organic Letters
, 2011, 13, 10, 2682-2685.

 

Synthesis of Conzyme Q10. Europeon Journal of Organic chemistry, 2012, 4954-4962.

 

Bis-sulfonic acid Ionic Liquids for the Conversion of Fructose to 5-Hydroxymethyl-2-furfural.
Molecules
, 2012, 17, 12804-12811.

 

Mechanism and Scope of the Mn-¥²-initiated Oxidation of beta-Ketocarbonyl Compounds ;
Furan Synthesis.
Europeon Journal of Organic chemistry, 2012, 6976-6985.

 

Combined Effect of Polar Substituents on the Electronic Flows in the Carotenoid Molecular Wire.
Chemistry: A
European Journal, 2013, 19, 10832-10835.

 

Sulfone-mediated syntheses of crocetin derivatives: regioselectivity of highly functionalized building blocks.
J. Org. Chem
, 2014, 79, 4712-4717.

 

Catalytic oxidation of ¥â-keto esters by manganese(III)/cobalt(II) and consecutive cyclization to heterocycles. Advanced Synthesis & Catalysis2014356, 3059-3066.

 

Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations.
Organic & Biomolecular Chemistry, 2015, 13, 2588-2599.

 

Synthesis of Tribenzotropone by Ring Expansion of Phenanthrene-9,10-dione.
Synthesis
, 2015, 47, 2957-2960.

 

Resonance Raman Spectra of Carotenoid Molecules: Influence of Methyl Substitutions.
Journal of Physical Chemistry A
, 2015, 119, 56-66.

 

Regioselective Synthesis of 1,3- and 1,2-Tocopheryl Glyceride Ethers of Carboxylic Acids.
European Journal of Organic Chemistry
, 2015, 2015, 514-524.

 

One-Pot Conversion of Carbohydrates into Pyrrole-2-carbaldehydes as Sustainable Platform Chemicals. Journal of Organic Chemistry, 2015, 80, 7693-7701.

 

Fine-Tuning of Single-Molecule Conductance by Tweaking Both Electronic Structure and Conformation of Side Substituents. Chemistry - A European Journal, 2015, 21, 7716-7720.

 

Enhanced biological activity of carotenoids stabilized by phenyl groups. Food chemistry, 2015, 177, 339-45.

 

A chain extension method for apocarotenoids; lycopene and lycophyll syntheses.
Archives of biochemistry and biophysics
, 2015, 572, 142-150.

 

Liquid-liquid extraction of lithium using lipophilic dibenzo-14-crown-4 ether carboxylic acid in hydrophobic room temperature ionic liquid. Hydrometallurgy, 2016, 164, 362-371.

 

Systematic Synthesis of Diphenyl-Substituted Carotenoids as Molecular Wires.
European Journal of Organic Chemistry
, 2017, 2017, 6390-6400.

 

Efficient preparation method of 4-hydroxybenzoic esters - Oxidation of substituted Hagemann's ester. Tetrahedron Letters, 2017, 58, 2264-2266.

 

Design of lithium selective crown ethers: Synthesis, extraction and theoretical binding studies.
Chem. Engineer. J., 2017, 326, 921-933.

 

Aethusifolins A–D: Four new components from a traditional Mongolian medicinal herb Clematis aethusifolia Turcz. Phytochem. Lett., 2017, 22, 87-91.

 

Aerosol Cross-Linked Crown Ether Diols Melded with Poly(vinyl alcohol) as Specialized Microfibrous Li+ Adsorbents. ACS Appl. Mater. Interfaces, 2017, 9, 42862-42874.

 

Role of Ring Ortho Substituents on the Configuration of Carotenoid Polyene Chains.
Organic Letters
, 2018, 20, 493-496.

 

Deprotection of durable benzenesulfonyl protection for phenols - efficient synthesis of polyphenols.
Synthetic Communications
, 2018, 48, 247-254.

 

Lycorin Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3.
Frontiers in Pharmacology, 2018, 9, 881

 

Fast Assembly and High-Throughput Screening of Structure and Antioxidant Relationship of Carotenoids.
Organic Letters, 2019, 21, 714-718.

 

Synthesis of Phenyl-2,2'-bichalcophenes and Their Aza-Analogues by Catalytic Oxidative Deacetylation. Synthesis, 2019, Ahead of Print.

 

Bromoacetate Olefination Protocol for Norbixin and Julia-Kocienski Olefination for Its Ester Syntheses
ACS Omega, 2019, 4, 10019-10024.

 

Aqueous Synthesis of 14-15-Membered Crown Ethers with Mixed O, N and S Heteroatoms: Experimental and Theoretical Binding Studies with Platinum-Group Metals
ChemPlusChem, 2019, 84, 210-221.

 

7-Deoxynarciclasine shows promising antitumor efficacy by targeting Akt against hepatocellular carcinoma
International journal of cancer, 2019, Ahead of Print.

 

 

 

     ¢Â  Àú ¼­

      ¡Ý  Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Allyl Trifluoromethanesulfonate Vol. 1, pp 130.
      ¡Ý  Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Bis(N-propylsalicylideneaminato)cobalt(II)
            Vol. 1, pp 552.

      ¡Ý  Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: 3-Nitro-9-nitrosocarbazole Vol. 6, pp 3747.
      ¡Ý  Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: N-Phenylcampholylhydroxamic Acid
            Vol. 6, pp 3965.
      ¡Ý  Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Thallium(I) Acetate Vol. 7, pp 4832.

     
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1994~1996

Retinol À¯µµÃ¼ ÇÕ¼º¿¡ °üÇÑ ¿¬±¸ (Çѱ¹°úÇÐÀç´Ü, »ïõ¸®Á¦¾à).

 

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1995~1997

µð¿Á½ÃÆú¸®ÇÁ·ÎÇÇ¿À³»ÀÌÆ®ÀÇ ÀÔü ¼±ÅÃÀû ÇÕ¼º (Çѱ¹°úÇÐÀç´Ü).

 

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1995~1996

Æú¸®ÇÁ·ÎÇÇ¿À³»ÀÌÆ®°è õ¿¬¹° Pectinatone°úLardolureÀÇ ÇÕ¼º¿¡ °üÇÑ ¿¬±¸
(Çѱ¹°úÇÐÀç´Ü, µµ³²»ê¾÷).

 

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1996~1998

º£Å¸-Ä«·Îƾ ÇÕ¼º¿¡ °üÇÑ ¿¬±¸ (Çѱ¹°úÇÐÀç´Ü, °æ±âµµ)

 

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1997.9~1999.8

¥á,¥â-unsaturated cyclic carbonyl È­ÇÕ¹°¿¡ °üÇÑ ¿¬±¸ (±³À°ºÎ, 1997-001-D00239)

 

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1999.12~2001.11

Æú¸®»çÀÌŬ¸¯ È­ÇÕ¹° ÇÕ¼º¿¡ °üÇÑ ¿¬±¸ (±³À°ºÎ, D00299)

 

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1996.6~2002.2

Æú¸®ÀΠüÀÎ È­ÇÕ¹° ÇÕ¼º¿¡ °üÇÑ ¿¬±¸ (Çѱ¹°úÇÐÀç´Ü, °æ±âµµ)