Prof. 구  상  호

    Tel :82-31-330-6185, Fax : 82-31-335-7248
    e-mail :
sangkoo@mju.ac.kr

    ◈학력

    1985: 서울대학교 자연과학대학 화학과 (학사)
    1987: The University of Michigan (Master in Chemistry)
    1992: The University of Michigan (Ph. D. in Chemistry)
    1992 ~ 1994: Emory University (Post-doctoral Fellow)


주요 경력

1994-1998 명지대학교 화학과 조교수
1998-1999 명지대학교 화학과 학과장
1998-2002 명지대학교 화학과 부교수
2006-2013 명지대학교 나노공학과 교수
2003-현재 명지대학교 화학과 교수

2006-현재 중국 화동이공대학교 Special Visiting Prof.
2013-현재 명지대학교 에너지융합공학과 겸임교수


전문 분야

새로운 유기합성 방법 개발,간단한 천연물의 합성,Palladium을 이용한 유기금속화학

연구 내용

카로티노이드계 화합물 합성법 개발: 비타민 A의 전위체이고 식용색소로 사용되고 있으며 최근에는 항암효과가 있는 것으로 알려진 카로티노이드계 화합물의 합성에 관한 연구. 카로티노이드계 화합물의 주요 구조를 이루고 있는 conjugate polyene chain의 효율적인 합성법 개발. Isoprene을 시작물질로 메틸 치환체의 위치를 달리하는 conjugate polyene unit의 합성.

입체선택적인 polypropionate chain 합성법 개발 및 이를 이용한 천연물의 합성 여러 항생제의 효능을 보이고 있는 천연물들의 구조에서 자주 발견되는 polypropionate 구조의 입체선택적인 합성법 개발. 육각형 고리구조를 기본으로 여기에 입체선택적인 방법으로 메틸 치환체를 붙이고 고리를 열어 메틸기의 다양한 입체구조를 갖는 polypropionate chain의 합성. 이의 입체구조를 기본으로 갖는 여러 polypropionate 계통의 천연물 합성.

다양한 고리구조 화합물 합성에 관한 연구 베타-케토에스테르 화합물을 이용하여 오각형, 육각형 등의 고리구조 화합물의 합성. 여러 천연물에서 자주 발견되는 2-시클로핵센-1-온 및 2-시클로펜텐-1-온의 효율적 합성법 개발. 위의 방법을 이용한 이중고리구조 화합물의 합성. 질소원소를 함유하는 헤테로고리 화합물의 합성.


주요 논문 실적

1,2-addition of Dimethyl(phenyl)silyllithium to Cyclic a,b-Unsaturated Ketones and Regiospecific Generation of Cyclic Silyl Enol Ethers through Brook Rearrangement of the1,2-AdditionProducts, Koreeda,M.;Koo,S. Tetrahedron Lett. 1990, 31, 831.

A General Synthetic Entry to Highly-Oxygenated, Angularly-Fused Polycyclic Aromatic Compound. Koo, S.; Liebeskind, L. J. Am. Chem. Soc. 1995, 117, 3389.

Allyl Trifluoromethanesulfonate, Koo, S. Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, vol 1, pp 130.

Thallium(I) Acetate, Koo, S. Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, vol 7, pp 4832.

N-Phenylcampholylhydroxamic Acid, Koo, S. Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, vol 6, pp 3965.

Bis(N-propylsalicylideneiminato)cobalt, Koo, S. Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, vol 1, pp 552.

3-Nitro-9-nitroso carbazole, Koo, S. Encyclopedia of Reagents for Organic Synthesis, Paquette, L. A. Ed, Wiley, London, 1995, vol 6, pp 3747vvvv.

Highly Efficient Synthesis of Methyl-Substituted Conjugate Cyclohexenones, Byong-Don Chong.; Yong-Il Ji.;Seong-Soo Oh.; Jea-Deuk Yang.; Sangho Koo. J. Org. Chem, 1997, 62, 9323.

Diallylic Sulfides as Key Structures for Carotenoid Syntheses, Hojin Choi.; Minkoo Ji.; Minsoo Park, In-Kyun Yun.; Seong-Soo Oh.; Sangho Koo. J. Org. Chem, 1999, 64, 8051.

 Highly Efficient Synthesis of Bicyclo[3.3.1]nonane Skeleton, Jae-Deuk Yang.; Moon-Soo Kim.; Miai Lee.; Woonphil Baik.; Sangho Koo.; Synthesis, 2000, 6,  801-804.

A Highly Efficient Chain-Extension Process in the Systematic Syntheses of Carotenoid Natural Products, Minkoo Ji.; Hojin Choi.; Minsoo Park.; Minyong Kee.; Young Cheol Jeong.; Sangho Koo. Angew. Chem. Int. Ed. 2001, 40(19), 3627.

Selective Oxidation of Allylic Sulfindes by Hydrogen Peroxide with the Trirutile-type Solide Oxide Catalyst LiNbMoO6, Soojin Choi.; Jae-Deuk Yang.; Minkoo Ji.; Hojin Choi.; Minyong Kee.; Kwang-Hyun Ahn.; Song-Ho Byeon.; Woonphil Baik.; Sangho Koo. J. Org. Chem. 2001, 66(24), 8192.

Mn(III)-Mediated Radical Cyclization for Δ1-Octalone Synthesis, Miai Lee.; Jae-Deuk Yang.; Moon-Soo Kim.; Hye-Sun Jeon.; Woonphil Baik.; Sangho Koo. Bull. Korean Chem. Soc. 2002, 23(5), 736.

Allylic sulfones containing triene moieties a key synthons for carotenoid synthesis, Minkoo Ji.; Hojin Choi.; Youngcheol.; Jingquan Jin.; Woonphil Baik.; Sijoon Lee.; Jeongsoo Kim.; Minsoo Park.; Sangho Koo. Helvetica Chimica Acta. 2003, 86(7), 2620.

The Friedel-Crafts Alylation of a Preny Group Stabilized by a Sulfone Moiety: Expeditious Syntheses of Ubiquinones and Menaquinones, Jae-Hong Min.; Jun-Sup Lee.; Jae-Deuk Yang.; Sangho Koo. J. Org. Chem. 2003, 68(20), 7925.

The intramolecular Baylis Hillman reaction: easy preparation of versatile substrates, facile reactions, and synthetic applications, Jung Eun Yeo.; Xiuling Yang.; Hee Jin Kim.; Sangho Koo. Chem. Commun., 2004, 236.

Highly Efficient and General Syntehtic Method of Various Retinyl Ethers, Jun-Sup Lee.; Young-Cheol Jeong.; Minkoo J.; Woonphil Baik.; Sijoon Lee.; Sangho Koo. Synlett., 2004, 11, 1937.

Preparetion of the conjugated polyene chains with the 1,4-dimethyl substitution, Hye-Sun Jeon.; Sangho Koo.; Tetrahedron Letters, 2004, 45(38), 7023.

General and systematic synthetic entry to carotenoid natural products, Young Cheol Jeong.; Minkoo Ji.; Jun-sup Lee.; Jae-Deuk Yang.; Jingquan Jin.; Woonphil Baik.; Sangho Koo.Tetrahedron, 2004, 60(45), 10181.

Stereoselective and Convergent Syntheses of Retinoic Acid and Its Ester Derivatives by the Sulfone Olefination Reaction, Hye Sun Jeon.; Jung Eun Yeo.; Sangho Koo. Synthesis, 2004, 17, 2813.

Efficient Syntheses of the Keto-carotenoids Canthaxanthin, Astaxanthin, and Astacene, Seyoung Choi.; Sangho Koo. J. Org. Chem., 2005, 70(8), 3328.

Preparation of 1,4-hydrobenzoquinones by the PCC/SiO2-promoted double oxidation of 3-cyclohexene-1,2-diols, Hee jin Kim.; Sangho Koo.Org.Biomol.Chem., 2005, 3, 3479.

Sulfone Coupling and Double-Elimination Strategy for Carotenoid Synthesis, Samar Kumar Guha.; Sangho Koo. J. Org. Chem., 2005, 70, 9662.

TMS·OTf-Catalyzed α-bromination of carbonyl compounds by N-bromosuccinimide,Samar Kumar Guha, Bo Wu, Beom Soo Kim, Woonphil Baik and Sangho Koo, Tetrahedron Letters.,47 (2006) 291. 

Origin of the Diastereoselection in the Indium-Mediated Addition of Haloallylic Sulfones to Aldehydes,Min, Jae-Hong; Jung, Se-Young; Wu, Bo; Oh, Jung Taek; Lah, Myoung Soo; Koo, Sangho, Organic Letters  (2006),  8(7),  1459-1462

Stereoselective Synthesis of Allylic Sulfones via the Oxonia-Cope Rearrangement of Homoallylic Alcohols Containing a Homoallylic Sulfone Moiety, Jung, Se-Young; Min, Jae-Hong; Oh, Jung Taek; Koo, Sangho,Journal of Organic Chemistry  (2006),  71(13),  4823-4828

Journal of Organic Chemistry 2008, 73, 1991-1994 (General Preparation and Controled Cyclization of Acyclic Terpenoids)

Advanced Synthesis & Catalysis 2008, 350, 365-369 (Expeditious and Practical Synthesis of  Lycopene)

Journal of Organic Chemistry 2009, 74, 917-920 (Ring-Expansion Protocol: Preparation of Synthetically Versatile Dihydrotropones)

Chemistry: A European Journal 2010, 16, 7395 - 7399 (Conductance Control in Stabilized Carotenoid Wires)

Pure and Applied Chemistry 2011, 83 , 3, 613 - 620 ( Convergent synthesis of new types of stabilized carotenoid compounds)

Physical Chemistry Chemical Physics 2011,13, 6340–6351 ( Ultrafast excited state dynamics and spectroscopy of 13,130-diphenyl-b-carotene)

Organic Letters 2011,13,10, 2682-2685 (Selective Deoxygenation of Allylic Alcohol: Stereocontrolled Synthesis of Lavandulol)

Europeon Journal of Organic chemistry ; 2012, 4954-4962 (Synthesis of Conzyme Q10)

Molecules ; 2012,17,12804-12811 (Bis-sulfonic acid Ionic Liquids for the Conversion of Fructose to 5-Hydroxymethyl-2-furfural)

Europeon Journal of Organic chemistry ; 2012, 6976-6985 (Mechanism and Scope of the Mn--initiated Oxidation of beta-Ketocarbonyl Compounds ; Furan Synthesis)

 

Chemistry: A European Journal  ; 2013, 19 10832-10835 (Combined Effect of Polar Substituents on the Electronic Flows in the Carotenoid Molecular Wire)

 

Journal of Organic Chemistry; 2014, 79(10), 4712-4717 (Sulfone-Mediated Syntheses of Crocetin Derivatives: Regioselectivity of Highly Functionalized Building Blocks)

   
   

 

저 서
 

Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Allyl Trifluoromethanesulfonate Vol. 1, pp 130.
Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Bis(N-propylsalicylideneaminato)cobalt(II) Vol. 1, pp     552.
◎ Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: 3-Nitro-9-nitrosocarbazole Vol. 6, pp 3747.
Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: N-Phenylcampholylhydroxamic Acid Vol. 6, pp 3965.
Encyclopedia of Reagents for Organic Synthesis, Wiley, 1995: Thallium(I) Acetate Vol. 7, pp 4832.

연구 실적

1994~1996

Retinol 유도체 합성에 관한 연구 (한국과학재단, 삼천리제약).

1995~1997

디옥시폴리프로피오내이트의 입체 선택적 합성 (한국과학재단).

1995~1996

폴리프로피오내이트계 천연물 Pectinatone과Lardolure의 합성에 관한 연구(한국과학재단, 도남산업).

1996~1998

베타-카로틴 합성에 관한 연구 (한국과학재단, 경기도)

1997.9~1999.8

α,β-unsaturated cyclic carbonyl 화합물에 관한 연구(교육부, 1997-001-D00239)

1999.12~2001.11

폴리사이클릭 화합물 합성에 관한 연구(교육부, D00299)

1996.6~2002.2

폴리인 체인 화합물 합성에 관한 연구(한국과학재단, 경기도)